Dashboard
A cellular-scale agent-based model of Mycobacterium tuberculosis granuloma formation. Adjust parameters, switch between host scenarios, and watch containment emerge — or fail.
Live simulation
TB granuloma formation
Emergingt = 0
Spatial view
MtbResting MφInfected MφActivated MφCD4+ T
Populations
Cytokine & burden
Presets
Parameters
Initial bacterial load
Seed burden at infection focus
0.35
Macrophage recruitment
Rate of resting Mφ entering from tissue edges
0.45
T-cell activation threshold
Cytokine level required for CD4+ recruitment
0.22
T-cell exhaustion
Dampens macrophage activation and IFN-γ signaling
0.10
Cytokine heatmap
Educational browser demo inspired by published agent-based models — not a calibrated reproduction. See Hoerter et al., mSystems 2025 and Frontiers in Immunology 2022.